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The study was done in 60 diabetic patients. These patients were divided into two groups, Group I (n=30) receiving Magnesium and Metformin therapy for a period of 16 weeks and Group II (n=30) receiving only Metformin therapy. The blood samples were collected and analyzed for Serum Magnesium and fasting blood glucose at 0, 4, 8, 16 weeks respectively. In GROUP I Mean Baseline value for S. Magnesium is 1.79±0.032 and after treatment values at 16 weeks 1.92±0.034. In this group we observed that S. Magnesium values before and after 16 weeks of magnesium supplementation was highly significant. In GROUP II Magnesium is 1.79±0.031 and after treatment values at 16 weeks this group there was no significant difference in S. Magnesium between before and after 16 weeks of treatment. In our study values for Mean fasting blood glucose level in group I before treatment (i.e. first visit) was 146.33±1.60 mg/dl compared to 127.07±0.96 mg/dl values of after treatment. This difference was considered highly Significant between before and after treatment values for fasting blood glucose levels (p<0.001)In group II values for mean fasting blood glucose level before treatment (i.e. first visit) was 145.5±1.81 mg/dl as compared to 136.53±1.31 mg/dl values of fasting blood glucose after treatment. This Difference was also considered Significant. ISSN: 2277-8713 IJPRBS